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| Amphotericin B ： ウィキペディア英語版 |
Amphotericin B
Amphotericin B is an antifungal drug often used intravenously for serious systemic fungal infections and is the only effective treatment for some fungal infections.〔(【引用サイトリンク】url = http://www.drugs.com/monograph/amphotericin-b.html )〕
Common side effects include a reaction of fever, shaking chills, headaches and low blood pressure soon after it is infused, as well as kidney and electrolyte problems.〔 Allergic symptoms including anaphylaxis may occur.〔
It was originally extracted from ''Streptomyces nodosus'', a filamentous bacterium, in 1955, at the Squibb Institute for Medical Research. Its name originates from the chemical's amphoteric properties. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.
It is of the polyene class. Currently, the drug is available in many forms. Either "conventionally" complexed with sodium deoxycholate (ABD), as a cholesteryl sulfate complex (ABCD), as a lipid complex (ABLC), and as a liposomal formulation (LAMB). The latter formulations have been developed to improve tolerability and decrease toxicity, but may show considerably different pharmacokinetic characteristics compared to conventional amphotericin B.〔
== Medical uses ==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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